Rheumatologie Köln - Dr. Niklas Baerlecken

Dr. med. Thomas Karger

Facharzt für Innere Medizin

Dr. med. Niklas Baerlecken

Internistischer Rheumatologe

Blücherstr. 5
50996 Köln

Tel.: 0221-30203610
Fax: 0221-30203619

E-Mail: ntbaerlecken@rheumapraxis-rodenkirchen.de



 

 

niedergelassener Rheumatologe in Köln seit 2017

07/2007-01/2015    Facharzt für Rheumatologie an der Medizinischen Hochschule Hannover

10/2007     Doktorarbeit „Weichteilsubstitution mit Hilfe von injizierten Präadipozyten". Labor Professor Stark, Plastische und Hand Chirurgie, Albert-Ludwigs-University Freiburg i. Br., Deutschland.

2003-2005     Rigorosum. Doctoral Supervisor: Prof. Dr. J. Borges; Albert-Ludwigs-University Freiburg i. Br., Deutschland, 2007

  2000-2007    Medizinstudium : Humanmedizin an der Albert-Ludwigs-Universität Freiburg im Breisgau

  2000    Abitur am Friedrich-Wilhelm-Gymnasium Köln 

 

 

2017               niedergelassener Rheumatologe in Köln
2016               Infektiologie
2014-2016       Rheumatologische Ambulanz
2013               Intensivmedizin
2012               Rheumatologie
2011               Infektiologie
2010               Gastroenterologie
2009               Klinische Immunologie
2007-2009       Notaufnahme
2007               Rheumatologie

 

Publikationen

Barturen G, Babaei S, Català-Moll F, Martínez-Bueno M, Makowska Z,  Baerlecken N, Kniesch K, Witte T, McDonald F, Pers JO, Alarcón-Riquelme ME. Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases. Arthritis Rheumatol. 2020 Dec 8. doi: 10.1002/art.41610. Online ahead of print.PMID: 33497037 

 

Le Lann L, Jouve PE, Alarcón-Riquelme M, Jamin C, Pers JO Standardization procedure for flow cytometry data harmonization in prospective multicenter studies. PRECISESADS Flow Cytometry Study Group; PRECISESADS Clinical Consortium.Sci Rep. 2020 Jul 14;10(1):11567. doi: 10.1038/s41598-020-68468-3.PMID: 32665668

 

Thiagarajan D, Oparina N, Lundström S, Zubarev R, Sun J; PRECISESADS Clinical Consortium, Alarcon-Riquelme M, Frostegård J. IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases. Sci Rep. 2020 Jul 3;10(1):11010. doi: 10.1038/s41598-020-66981-z.PMID: 32620913 

 

Witte T, Köhler M, Georgi J, Schweikhard E, Matthias T, Baerlecken N, Hermann KG, Sieper J, Rudwaleit M, Poddubnyy D. IgA antibodies against CD74 are associated with structural damage in the axial skeleton in patients with axial spondyloarthritis. Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1127-1131. Epub 2020 Mar 28.PMID: 32242816 

 

van Kempen TS, Leijten EFA, Lindenbergh MFS, Nordkamp MO, Driessen C, Lebbink RJ, Baerlecken N, Witte T, Radstake TRDJ, Boes M. Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis. Eur J Immunol. 2020 Aug;50(8):1209-1219. doi: 10.1002/eji.201948502. Epub 2020 Apr 14.PMID: 32198923 

 

Baerlecken N, Pursche N, Witte T, Kniesch K, Höpfner M, Ernst D, Moosig F, Seeliger B, Prasse A.J Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis. Clin Med. 2020 Mar 6;9(3):715. doi: 10.3390/jcm9030715.PMID: 32155774 

 

Baerlecken NT, Gaulke R, Pursche N, Witte T, Karst M, Bernateck M. Autoantibodies against P29ING4 are associated with complex regional pain syndrome. Immunol Res. 2019 Dec;67(6):461-468. doi: 10.1007/s12026-020-09114-y.

 

Sogkas G, Klose K, Baerlecken N, Schweikhard E, Matthias T, Kniesch K, Schmidt RE, Witte T.
CD74 is a T cell antigen in spondyloarthritis. Clin Exp Rheumatol. 2019 May 22. [Epub ahead of print]

 

Ziade NR, Mallak I, Merheb G, Ghorra P, Baerlecken N, Witte T, Baraliakos X. Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence.
Front Immunol. 2019 Mar 26;10:574. doi: 10.3389/fimmu.2019.00574. eCollection 2019.

 

Riechers E, Baerlecken N, Baraliakos X, Achilles-Mehr Bakhsh K, Aries P, Bannert B, Becker K, Brandt-Jürgens J, Braun J, Ehrenstein B, Euler HH, Fleck M, Hein R, Karberg K, Köhler L, Matthias T, Max R, Melzer A, Meyer-Olson D, Rech J, Rockwitz K, Rudwaleit M, Schmidt RE, Schweikhard E, Sieper J, Stille C, von Hinüber U, Wagener P, Weidemann HF, Zinke S, Witte T. Sensitivity and Specificity of Autoantibodies Against CD74 in Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2019 May;71(5):729-735. doi: 10.1002/art.40777. Epub 2019 Mar 20.

 

de Winter JJ, van de Sande MG, Baerlecken N, Berg I, Ramonda R, van der Heijde D, van Gaalen FA, Witte T, Baeten DL. Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort. Arthritis Res Ther. 2018 Mar 1;20(1):38. doi: 10.1186/s13075-018-1535-x.


[New biomarkers for large vessel vasculitis and spondyloarthropathies].
Baerlecken NT.
Z Rheumatol. 2017 May 19. doi: 10.1007/s00393-017-0323-3. [Epub ahead of print] German. No abstract available.
PMID:  28527043

Anti-MYC-associated zinc finger protein antibodies are associated with inflammatory atherosclerotic lesions on 18F-fluorodeoxyglucose positron emission tomography.
Ernst D, Weiberg D, Baerlecken NT, Schlumberger W, Daehnrich C, Schmidt RE, Bengel FM, Derlin T, Witte T.
Atherosclerosis. 2017 Apr;259:12-19. doi: 10.1016/j.atherosclerosis.2017.02.010. Epub 2017 Feb 20.
PMID:  28279832

Evaluation of RAG1 mutations in an adult with combined immunodeficiency and progressive multifocal leukoencephalopathy.
Schröder C, Baerlecken NT, Pannicke U, Dörk T, Witte T, Jacobs R, Stoll M, Schwarz K, Grimbacher B, Schmidt RE, Atschekzei F.
Clin Immunol. 2017 Feb 20;179:1-7. doi: 10.1016/j.clim.2016.12.013. [Epub ahead of print]
PMID:  28216420

Gain-of-function STAT1 mutations are associated with intracranial aneurysms.
Dadak M, Jacobs R, Skuljec J, Jirmo AC, Yildiz Ö, Donnerstag F, Baerlecken NT, Schmidt RE, Lanfermann H, Skripuletz T, Schwenkenbecher P, Kleinschnitz C, Tumani H, Stangel M, Pul R.
Clin Immunol. 2017 May;178:79-85. doi: 10.1016/j.clim.2017.01.012. Epub 2017 Feb 2.
PMID:  28161409

Two Subsets of Large Vessel Vasculitis Characterized by the Absence or Presence of Spondyloarthritis or its Associated Diseases.
Ernst D, Bearlecken N, Ernst Schmidt R, Witte T.
Open Rheumatol J. 2016 Nov 30;10:101-108. doi: 10.2174/1874312901610010101. eCollection 2016.
PMID: 28077977 Free PMC Article

Increased T-cell turnover is associated with spondyloarthritis in virally suppressed patients with HIV-1 infection.
Lu IN, Meyer-Olson D, Stoll M, Witte T, Schmidt RE, Baerlecken NT.
HIV Med. 2015 Apr;16(4):255-60. doi: 10.1111/hiv.12199. Epub 2014 Sep 23.
PMID:  25252008  Free Article

Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections.
Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT.
HIV Med. 2015 Feb;16(2):114-21. doi: 10.1111/hiv.12194. Epub 2014 Sep 12.
PMID:  25213431  Free Article

Association of ferritin antibodies with Takayasu arteritis.
Große K, Witte T, Moosig F, Hoyer BF, Lansche C, Schmidt RE, Baerlecken NT.
Clin Rheumatol. 2014;33(10):1523-6. doi: 10.1007/s10067-014-2764-2. Epub 2014 Sep 2.
PMID:  25178778

Large vessel vasculitis and spondyloarthritis: coincidence or associated diseases?
Ernst D, Baerlecken NT, Schmidt RE, Witte T.
Scand J Rheumatol. 2014;43(3):246-8. doi: 10.3109/03009742.2013.850737. Epub 2014 Jan 19.
PMID:  24438209

Autoantibodies against CD74 in spondyloarthritis.
Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, Matthias T, Schmidt RE, Witte T.
Ann Rheum Dis. 2014 Jun;73(6):1211-4. doi: 10.1136/annrheumdis-2012-202208. Epub 2013 May 17.
PMID:  23687263


Epitope mapping of antibodies against ferritin heavy chain in giant cell arteritis and polymyalgia rheumatica.
Große K, Schmidt RE, Witte T, Baerlecken NT.
Scand J Rheumatol. 2013;42(3):215-9. doi: 10.3109/03009742.2012.733959.
PMID:  23682607

High prevalence of anti-CD74 antibodies specific for the HLA class II-associated invariant chain peptide (CLIP) in patients with axial spondyloarthritis.
Baraliakos X, Baerlecken N, Witte T, Heldmann F, Braun J.
Ann Rheum Dis. 2014 Jun;73(6):1079-82. doi: 10.1136/annrheumdis-2012-202177. Epub 2013 May 3.
PMID:  23644552

[Adult onset Still's disease, fever, diagnosis and therapy].
Baerlecken NT, Schmidt RE.
Z Rheumatol. 2012 Apr;71(3):174-80. doi: 10.1007/s00393-011-0859-6. Review. German.
PMID:  22527211

Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica.
Baerlecken NT, Linnemann A, Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay MA, Martin J, Kötter I, Henes JC, Melchers I, Vaith P, Schmidt RE, Witte T.
Ann Rheum Dis. 2012 Jun;71(6):943-7. doi: 10.1136/annrheumdis-2011-200413. Epub 2012 Jan 5.
PMID:  22228484

[Reactivation of tuberculosis with Mycobacterium bovis infection of the oral mucosa during immunosuppression].
Ernst D, Bange FC, Rana A, Baerlecken N, Puls F, Schmidt RE, Stoll M.
Dtsch Med Wochenschr. 2010 Jun;135(23):1179-81. doi: 10.1055/s-0030-1255127. Epub 2010 May 31. German.
PMID:  20514598

Essential mixed cryoglobulinemia type III with leukocytoclastic vasculitis: remission by rituximab.
Baerlecken NT, Schmidt RE.
Clin Rheumatol. 2013 Mar;32 Suppl 1:S19-20. doi: 10.1007/s10067-010-1412-8. Epub 2010 Mar 7.
PMID:  20213127


Recurrent, multifocal Mycobacterium avium-intercellulare infection in a patient with interferon-gamma autoantibody.
Baerlecken N, Jacobs R, Stoll M, Schmidt RE, Witte T.
Clin Infect Dis. 2009 Oct 1;49(7):e76-8. doi: 10.1086/605581.
PMID:  19725781

[Eosinophilic fasciitis and asplenia].
Baerlecken NT, Melzer A, Schmidt RE, Witte T.
Z Rheumatol. 2009 Oct;68(8):695-6, 698. doi: 10.1007/s00393-009-0478-7. German.
PMID:  19513726

Engineering of adipose tissue by injection of human preadipocytes in fibrin.
Torio-Padron N, Baerlecken N, Momeni A, Stark GB, Borges J.
Aesthetic Plast Surg. 2007 May-Jun;31(3):285-93.
PMID:  17380359

Patente

EP2420834 - Methods and means for diagnosing spondyloarthritis using autoantibody markers
EP2482074 - Methods and means for diagnosing vasculitis
⦁    EP12194134.8 - Analysis for adult-onset Still´s disease
⦁    EP2816354A1 - Biomarker for complex regional pain syndrome (CRPS)
⦁    EP3121599 A1- Analysis for atherosclerosis
⦁    Patent for Autoimmune hepatitis in progress


 

 

 

Dr. med. Thomas Karger
Dr. med. Niklas Baerlecken

Blücherstr. 5
50996 Köln
Ärztekammer: Ärztekammer Nordrhein

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