Rheumatologie Köln - Dr. Niklas Baerlecken
Dr. med. Thomas Karger
Facharzt für Innere Medizin
Dr. med. Niklas Baerlecken
Internistischer Rheumatologe
Blücherstr. 5
50996 Köln
Tel.: 0221-30203610
Fax: 0221-30203619
E-Mail: ntbaerlecken@rheumapraxis-rodenkirchen.de
niedergelassener Rheumatologe in Köln seit 2017
07/2007-01/2015 Facharzt für Rheumatologie an der Medizinischen Hochschule Hannover
10/2007 Doktorarbeit „Weichteilsubstitution mit Hilfe von injizierten Präadipozyten". Labor Professor Stark, Plastische und Hand Chirurgie, Albert-Ludwigs-University Freiburg i. Br., Deutschland.
2003-2005 Rigorosum. Doctoral Supervisor: Prof. Dr. J. Borges; Albert-Ludwigs-University Freiburg i. Br., Deutschland, 2007
2000-2007 Medizinstudium : Humanmedizin an der Albert-Ludwigs-Universität Freiburg im Breisgau
2000 Abitur am Friedrich-Wilhelm-Gymnasium Köln
2017 niedergelassener Rheumatologe in Köln
2016 Infektiologie
2014-2016 Rheumatologische Ambulanz
2013 Intensivmedizin
2012 Rheumatologie
2011 Infektiologie
2010 Gastroenterologie
2009 Klinische Immunologie
2007-2009 Notaufnahme
2007 Rheumatologie
Publikationen
Barturen G, Babaei S, Català-Moll F, Martínez-Bueno M, Makowska Z, Baerlecken N, Kniesch K, Witte T, McDonald F, Pers JO, Alarcón-Riquelme ME. Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases. Arthritis Rheumatol. 2020 Dec 8. doi: 10.1002/art.41610. Online ahead of print.PMID: 33497037
Le Lann L, Jouve PE, Alarcón-Riquelme M, Jamin C, Pers JO Standardization procedure for flow cytometry data harmonization in prospective multicenter studies. PRECISESADS Flow Cytometry Study Group; PRECISESADS Clinical Consortium.Sci Rep. 2020 Jul 14;10(1):11567. doi: 10.1038/s41598-020-68468-3.PMID: 32665668
Thiagarajan D, Oparina N, Lundström S, Zubarev R, Sun J; PRECISESADS Clinical Consortium, Alarcon-Riquelme M, Frostegård J. IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases. Sci Rep. 2020 Jul 3;10(1):11010. doi: 10.1038/s41598-020-66981-z.PMID: 32620913
Witte T, Köhler M, Georgi J, Schweikhard E, Matthias T, Baerlecken N, Hermann KG, Sieper J, Rudwaleit M, Poddubnyy D. IgA antibodies against CD74 are associated with structural damage in the axial skeleton in patients with axial spondyloarthritis. Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1127-1131. Epub 2020 Mar 28.PMID: 32242816
van Kempen TS, Leijten EFA, Lindenbergh MFS, Nordkamp MO, Driessen C, Lebbink RJ, Baerlecken N, Witte T, Radstake TRDJ, Boes M. Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis. Eur J Immunol. 2020 Aug;50(8):1209-1219. doi: 10.1002/eji.201948502. Epub 2020 Apr 14.PMID: 32198923
Baerlecken N, Pursche N, Witte T, Kniesch K, Höpfner M, Ernst D, Moosig F, Seeliger B, Prasse A.J Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis. Clin Med. 2020 Mar 6;9(3):715. doi: 10.3390/jcm9030715.PMID: 32155774
Baerlecken NT, Gaulke R, Pursche N, Witte T, Karst M, Bernateck M. Autoantibodies against P29ING4 are associated with complex regional pain syndrome. Immunol Res. 2019 Dec;67(6):461-468. doi: 10.1007/s12026-020-09114-y.
Sogkas G, Klose K, Baerlecken N, Schweikhard E, Matthias T, Kniesch K, Schmidt RE, Witte T.
CD74 is a T cell antigen in spondyloarthritis. Clin Exp Rheumatol. 2019 May 22. [Epub ahead of print]
Ziade NR, Mallak I, Merheb G, Ghorra P, Baerlecken N, Witte T, Baraliakos X. Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence.
Front Immunol. 2019 Mar 26;10:574. doi: 10.3389/fimmu.2019.00574. eCollection 2019.
Riechers E, Baerlecken N, Baraliakos X, Achilles-Mehr Bakhsh K, Aries P, Bannert B, Becker K, Brandt-Jürgens J, Braun J, Ehrenstein B, Euler HH, Fleck M, Hein R, Karberg K, Köhler L, Matthias T, Max R, Melzer A, Meyer-Olson D, Rech J, Rockwitz K, Rudwaleit M, Schmidt RE, Schweikhard E, Sieper J, Stille C, von Hinüber U, Wagener P, Weidemann HF, Zinke S, Witte T. Sensitivity and Specificity of Autoantibodies Against CD74 in Nonradiographic Axial Spondyloarthritis. Arthritis Rheumatol. 2019 May;71(5):729-735. doi: 10.1002/art.40777. Epub 2019 Mar 20.
de Winter JJ, van de Sande MG, Baerlecken N, Berg I, Ramonda R, van der Heijde D, van Gaalen FA, Witte T, Baeten DL. Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort. Arthritis Res Ther. 2018 Mar 1;20(1):38. doi: 10.1186/s13075-018-1535-x.
[New biomarkers for large vessel vasculitis and spondyloarthropathies].
Baerlecken NT.
Z Rheumatol. 2017 May 19. doi: 10.1007/s00393-017-0323-3. [Epub ahead of print] German. No abstract available.
PMID: 28527043
Anti-MYC-associated zinc finger protein antibodies are associated with inflammatory atherosclerotic lesions on 18F-fluorodeoxyglucose positron emission tomography.
Ernst D, Weiberg D, Baerlecken NT, Schlumberger W, Daehnrich C, Schmidt RE, Bengel FM, Derlin T, Witte T.
Atherosclerosis. 2017 Apr;259:12-19. doi: 10.1016/j.atherosclerosis.2017.02.010. Epub 2017 Feb 20.
PMID: 28279832
Evaluation of RAG1 mutations in an adult with combined immunodeficiency and progressive multifocal leukoencephalopathy.
Schröder C, Baerlecken NT, Pannicke U, Dörk T, Witte T, Jacobs R, Stoll M, Schwarz K, Grimbacher B, Schmidt RE, Atschekzei F.
Clin Immunol. 2017 Feb 20;179:1-7. doi: 10.1016/j.clim.2016.12.013. [Epub ahead of print]
PMID: 28216420
Gain-of-function STAT1 mutations are associated with intracranial aneurysms.
Dadak M, Jacobs R, Skuljec J, Jirmo AC, Yildiz Ö, Donnerstag F, Baerlecken NT, Schmidt RE, Lanfermann H, Skripuletz T, Schwenkenbecher P, Kleinschnitz C, Tumani H, Stangel M, Pul R.
Clin Immunol. 2017 May;178:79-85. doi: 10.1016/j.clim.2017.01.012. Epub 2017 Feb 2.
PMID: 28161409
Two Subsets of Large Vessel Vasculitis Characterized by the Absence or Presence of Spondyloarthritis or its Associated Diseases.
Ernst D, Bearlecken N, Ernst Schmidt R, Witte T.
Open Rheumatol J. 2016 Nov 30;10:101-108. doi: 10.2174/1874312901610010101. eCollection 2016.
PMID: 28077977 Free PMC Article
Increased T-cell turnover is associated with spondyloarthritis in virally suppressed patients with HIV-1 infection.
Lu IN, Meyer-Olson D, Stoll M, Witte T, Schmidt RE, Baerlecken NT.
HIV Med. 2015 Apr;16(4):255-60. doi: 10.1111/hiv.12199. Epub 2014 Sep 23.
PMID: 25252008 Free Article
Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections.
Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT.
HIV Med. 2015 Feb;16(2):114-21. doi: 10.1111/hiv.12194. Epub 2014 Sep 12.
PMID: 25213431 Free Article
Association of ferritin antibodies with Takayasu arteritis.
Große K, Witte T, Moosig F, Hoyer BF, Lansche C, Schmidt RE, Baerlecken NT.
Clin Rheumatol. 2014;33(10):1523-6. doi: 10.1007/s10067-014-2764-2. Epub 2014 Sep 2.
PMID: 25178778
Large vessel vasculitis and spondyloarthritis: coincidence or associated diseases?
Ernst D, Baerlecken NT, Schmidt RE, Witte T.
Scand J Rheumatol. 2014;43(3):246-8. doi: 10.3109/03009742.2013.850737. Epub 2014 Jan 19.
PMID: 24438209
Autoantibodies against CD74 in spondyloarthritis.
Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, Matthias T, Schmidt RE, Witte T.
Ann Rheum Dis. 2014 Jun;73(6):1211-4. doi: 10.1136/annrheumdis-2012-202208. Epub 2013 May 17.
PMID: 23687263
Epitope mapping of antibodies against ferritin heavy chain in giant cell arteritis and polymyalgia rheumatica.
Große K, Schmidt RE, Witte T, Baerlecken NT.
Scand J Rheumatol. 2013;42(3):215-9. doi: 10.3109/03009742.2012.733959.
PMID: 23682607
High prevalence of anti-CD74 antibodies specific for the HLA class II-associated invariant chain peptide (CLIP) in patients with axial spondyloarthritis.
Baraliakos X, Baerlecken N, Witte T, Heldmann F, Braun J.
Ann Rheum Dis. 2014 Jun;73(6):1079-82. doi: 10.1136/annrheumdis-2012-202177. Epub 2013 May 3.
PMID: 23644552
[Adult onset Still's disease, fever, diagnosis and therapy].
Baerlecken NT, Schmidt RE.
Z Rheumatol. 2012 Apr;71(3):174-80. doi: 10.1007/s00393-011-0859-6. Review. German.
PMID: 22527211
Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica.
Baerlecken NT, Linnemann A, Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay MA, Martin J, Kötter I, Henes JC, Melchers I, Vaith P, Schmidt RE, Witte T.
Ann Rheum Dis. 2012 Jun;71(6):943-7. doi: 10.1136/annrheumdis-2011-200413. Epub 2012 Jan 5.
PMID: 22228484
[Reactivation of tuberculosis with Mycobacterium bovis infection of the oral mucosa during immunosuppression].
Ernst D, Bange FC, Rana A, Baerlecken N, Puls F, Schmidt RE, Stoll M.
Dtsch Med Wochenschr. 2010 Jun;135(23):1179-81. doi: 10.1055/s-0030-1255127. Epub 2010 May 31. German.
PMID: 20514598
Essential mixed cryoglobulinemia type III with leukocytoclastic vasculitis: remission by rituximab.
Baerlecken NT, Schmidt RE.
Clin Rheumatol. 2013 Mar;32 Suppl 1:S19-20. doi: 10.1007/s10067-010-1412-8. Epub 2010 Mar 7.
PMID: 20213127
Recurrent, multifocal Mycobacterium avium-intercellulare infection in a patient with interferon-gamma autoantibody.
Baerlecken N, Jacobs R, Stoll M, Schmidt RE, Witte T.
Clin Infect Dis. 2009 Oct 1;49(7):e76-8. doi: 10.1086/605581.
PMID: 19725781
[Eosinophilic fasciitis and asplenia].
Baerlecken NT, Melzer A, Schmidt RE, Witte T.
Z Rheumatol. 2009 Oct;68(8):695-6, 698. doi: 10.1007/s00393-009-0478-7. German.
PMID: 19513726
Engineering of adipose tissue by injection of human preadipocytes in fibrin.
Torio-Padron N, Baerlecken N, Momeni A, Stark GB, Borges J.
Aesthetic Plast Surg. 2007 May-Jun;31(3):285-93.
PMID: 17380359
Patente
EP2420834 - Methods and means for diagnosing spondyloarthritis using autoantibody markers
EP2482074 - Methods and means for diagnosing vasculitis
⦁ EP12194134.8 - Analysis for adult-onset Still´s disease
⦁ EP2816354A1 - Biomarker for complex regional pain syndrome (CRPS)
⦁ EP3121599 A1- Analysis for atherosclerosis
⦁ Patent for Autoimmune hepatitis in progress
Dr. med. Thomas Karger
Dr. med. Niklas Baerlecken
Blücherstr. 5
50996 Köln
Ärztekammer: Ärztekammer Nordrhein
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